脑型疟疾期间大脑中脾分化和 CCR5+CXCL9+CXCL10 单核细胞衍生树突状细胞的出现。
Splenic differentiation and emergence of CCR5CXCL9CXCL10 monocyte-derived dendritic cells in the brain during cerebral malaria.
机构信息
Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Av. Augusto de Lima 1715, Barro Preto, Belo Horizonte MG 30190-002, Brazil.
Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, 149 Thirteenth Street, Charlestown, Massachusetts 02129, USA.
出版信息
Nat Commun. 2016 Nov 3;7:13277. doi: 10.1038/ncomms13277.
Dendritic cells have an important role in immune surveillance. After being exposed to microbial components, they migrate to secondary lymphoid organs and activate T lymphocytes. Here we show that during mouse malaria, splenic inflammatory monocytes differentiate into monocyte-derived dendritic cells (MO-DCs), which are CD11bF4/80CD11cMHCIIDC-SIGNLy6c and express high levels of CCR5, CXCL9 and CXCL10 (CCR5CXCL9/10 MO-DCs). We propose that malaria-induced splenic MO-DCs take a reverse migratory route. After differentiation in the spleen, CCR5CXCL9/10 MO-DCs traffic to the brain in a CCR2-independent, CCR5-dependent manner, where they amplify the influx of CD8 T lymphocytes, leading to a lethal neuropathological syndrome.
树突状细胞在免疫监视中具有重要作用。在接触微生物成分后，它们迁移到次级淋巴器官并激活 T 淋巴细胞。在这里，我们表明在小鼠疟疾期间，脾脏炎症性单核细胞分化为单核细胞衍生的树突状细胞（MO-DC），其特征为 CD11bF4/80CD11cMHCIIDC-SIGNLy6c，并表达高水平的 CCR5、CXCL9 和 CXCL10（CCR5CXCL9/10 MO-DC）。我们提出，疟疾诱导的脾脏 MO-DC 采取逆行迁移途径。在脾脏中分化后，CCR5CXCL9/10 MO-DC 以 CCR2 非依赖性、CCR5 依赖性方式迁移到大脑，在那里它们扩增 CD8 T 淋巴细胞的流入，导致致命的神经病理综合征。
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