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测量小鼠战斗行为和运动活动的自动化方法。

Automated method for measuring fighting behavior and locomotor activity of mice.

作者信息

Päivärinta P, Korpi E R

机构信息

Research Laboratories, Alko Ltd., Helsinki, Finland.

出版信息

Physiol Behav. 1989 Apr;45(4):857-60. doi: 10.1016/0031-9384(89)90307-7.

DOI:10.1016/0031-9384(89)90307-7
PMID:2780859
Abstract

A multiunit apparatus for automatic quantification of intermale fighting behavior and locomotor activity of mice is described. The method uses static charge sensitive beds (SCSB) to detect movement, and appropriate hard- and software for data acquisition and analysis. The data obtained with the SCSB-method correlated well with those observed from video-recordings of the same 60 aggression trials for determining both the total fighting times (r = .967) and the latencies to first fighting (r = .982). d-Amphetamine significantly increased locomotor activity counts on the SCSBs, and this increase was blocked by haloperidol. It is concluded, that the SCSB-method is an accurate and flexible technique for quantifying intermale fighting behavior and locomotor activity of mice.

摘要

本文描述了一种用于自动定量小鼠雄性间争斗行为和运动活动的多单元装置。该方法使用静电敏感床(SCSB)来检测运动,并使用适当的硬件和软件进行数据采集和分析。通过SCSB方法获得的数据与从相同60次攻击试验的视频记录中观察到的数据在确定总争斗时间(r = 0.967)和首次争斗潜伏期(r = 0.982)方面具有良好的相关性。右旋苯丙胺显著增加了SCSB上的运动活动计数,并且这种增加被氟哌啶醇阻断。得出的结论是,SCSB方法是一种准确且灵活的技术,可用于定量小鼠雄性间争斗行为和运动活动。

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