Hodge G K, Butcher L L
Eur J Pharmacol. 1975 Mar;31(1):81-93. doi: 10.1016/0014-2999(75)90081-3.
Drugs differentially affecting catecholaminergic neurotransmission mechanisms were injected into isolated mice to assess effects on aggression. L-DOPA in combination with a peripheral decarboxylase inhibitor produced a dose-dependent decrease in the number of fights and average fight durations accompanied by an increase in attack latencies. Central dopamine levels were increased whilst brain noradrenaline and 5-hydroxytryptamine were reduced. Virtually identical effects on aggression were observed after apomorphine. Pimozide decreased fighting, but neither attack latencies nor average fight durations were effected. All doses of disulfiram virtually abolished all components of aggressive responses. The effect of D-amphetamine on number of fights was biphasic; lower doses potentiated aggression, but higher doses reduced fighting accompanied by increased attack latencies and reduced average fight durations. We conclude that catecholamines may be intimately involved in mediating certain components of aggressive responses but that balance relationships among various putative neurotransmitters may be a more meaningful correlate of this behavior.
将不同影响儿茶酚胺能神经传递机制的药物注射到离体小鼠体内，以评估其对攻击行为的影响。左旋多巴与外周脱羧酶抑制剂联合使用，可使打斗次数和平均打斗持续时间呈剂量依赖性减少，同时攻击潜伏期延长。中枢多巴胺水平升高，而脑去甲肾上腺素和5-羟色胺水平降低。阿扑吗啡给药后对攻击行为产生了几乎相同的影响。匹莫齐特可减少打斗，但对攻击潜伏期和平均打斗持续时间均无影响。所有剂量的双硫仑几乎消除了攻击反应的所有组成部分。右旋苯丙胺对打斗次数的影响呈双相性；低剂量增强攻击行为，高剂量则减少打斗，同时攻击潜伏期延长，平均打斗持续时间缩短。我们得出结论，儿茶酚胺可能密切参与介导攻击反应的某些组成部分，但各种假定神经递质之间的平衡关系可能是这种行为更有意义的关联因素。
