Buntin J D
Department of Biological Sciences, University of Wisconsin-Milwaukee 53201.
Physiol Behav. 1989 May;45(5):903-9. doi: 10.1016/0031-9384(89)90213-8.
Intracranial injections of prolactin (PRL) have been previously shown to elevate food and water intake in ring doves. In an attempt to further characterize these PRL-induced behavioral responses and the time course of PRL action, food and/or water intake were measured as frequent intervals in male doves given a single intracerebroventricular (ICV) injection of ovine PRL (44 pmoles) or vehicle under food deprivation, water deprivation, or nondeprivation conditions. PRL increased food consumption by 35-50% over baseline levels in water deprived and nondeprived doves, although response latencies (10 hr) and durations (greater than 24 hr) were considerably longer than those reported for other orexigenic peptides. Behavioral observations of nondeprived doves further revealed that PRL significantly increased total time spent feeding and average feeding bout duration. In contrast to this pattern, water intake remained unchanged in food deprived doves and was only marginally increased in nondeprived doves following PRL treatment. Collectively, these results suggest that PRL promotes a selective and long-lasting hyperphagia which may in turn augment drinking activity.
先前的研究表明，向家鸽颅内注射催乳素（PRL）会增加其食物和水的摄入量。为了进一步描述这些PRL诱导的行为反应以及PRL作用的时间进程，在食物剥夺、水剥夺或非剥夺条件下，对单次脑室内（ICV）注射羊PRL（44皮摩尔）或赋形剂的雄性家鸽，以频繁的时间间隔测量其食物和/或水的摄入量。在缺水和未缺水的家鸽中，PRL使食物摄入量比基线水平增加了35%-50%，尽管反应潜伏期（10小时）和持续时间（超过24小时）比其他促食欲肽的报告要长得多。对未缺水家鸽的行为观察进一步表明，PRL显著增加了进食总时间和平均进食回合持续时间。与这种模式相反，在食物剥夺的家鸽中，水的摄入量没有变化，而在PRL处理后的未缺水家鸽中，水的摄入量仅略有增加。总体而言，这些结果表明，PRL促进了选择性和持久的食欲亢进，这反过来可能会增加饮水活动。
