Wang Shun, Jiang Jun, Qu Chuncheng, Wang Chengwei, Sun Zhaohui
Department of Clinical Laboratory, The Second Hospital, Shandong University, Jinan, Shandong, China.
Department of Neurosurgery, The Second Hospital, Shandong University, Jinan, Shandong, China.
J Clin Lab Anal. 2017 Sep;31(5). doi: 10.1002/jcla.22091. Epub 2016 Nov 3.
To investigate the role of pregnancy-associated plasma protein A (PAPP-A) in the outcome of ischemic cerebrovascular disease.
We analyzed the levels of PAPP-A in the transient ischemic attack (TIA) patients, ischemic stroke (IS) patients and normal control, and followed up the outcome of the patients in the following 2 years. Blood samples were drawn at admission, prior to treatment with heparins.
The levels of PAPP-A in TIA patients, IS patients and normal control were 4.91 (2.11, 6.48) mIU/L, 6.77 (3.31, 10.23) mIU/L and 4.25 (1.76, 5.22) mIU/L, respectively. The follow-up results of TIA patients and IS patients indicated the PAPP-A concentration in the poor prognosis group were higher than those in the good prognosis group (5.90 vs 4.46 mIU/L, P<.05, 10.06 vs 5.12 mIU/L, P<.05, respectively). Serum PAPP-A concentration emerged as a predictor of risk stratification with an OR of 1.41 and 1.25 (P<.05, P<.05).
Higher PAPP-A concentration has a forecasting value on prognosis in ischemic cerebrovascular disease.
探讨妊娠相关血浆蛋白A（PAPP-A）在缺血性脑血管病预后中的作用。
分析短暂性脑缺血发作（TIA）患者、缺血性卒中（IS）患者及正常对照者的PAPP-A水平，并对患者进行为期2年的预后随访。在入院时、肝素治疗前采集血样。
TIA患者、IS患者及正常对照者的PAPP-A水平分别为4.91（2.11，6.48）mIU/L、6.77（3.31，10.23）mIU/L和4.25（1.76，5.22）mIU/L。TIA患者和IS患者的随访结果显示，预后不良组的PAPP-A浓度高于预后良好组（分别为5.90 vs 4.46 mIU/L，P<0.05；10.06 vs 5.12 mIU/L，P<0.05）。血清PAPP-A浓度可作为风险分层的预测指标，OR值分别为1.41和1.25（P<0.05，P<0.05）。
较高的PAPP-A浓度对缺血性脑血管病的预后具有预测价值。
