Li Baoshan, Geng Shouke, Dai Yuanli
Department of Neurosurgery, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China.
Department of Neuro-Rehabilitation, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China.
Exp Ther Med. 2018 Aug;16(2):891-895. doi: 10.3892/etm.2018.6271. Epub 2018 Jun 7.
Therapeutic effect of vascular interventional therapy and aspirin combined with defibrase in the treatment of cerebral ischemia in rat model were investigated. Ninety rats were selected to establish cerebral ischemia model. Animal models were randomly divided into observation group and control group, with 45 rats in each group. Rats in observation group were treated with vascular intervention, and control group was treated with aspirin combined with defibrase. Peak systolic velocity (Vs) and end-diastolic velocity (Vd) were compared between two groups before and after 12 months of treatment. Therapeutic effects were compared before and after 6 months, and before and after 12 months of treatment. Vs and Vd of vascular lesions in observation group at 12 months were reduced after treatment, and were significantly lower than those in control group (p<0.05). After treatment, Vs and Vd in observation group were significantly reduced (p<0.05). There was no significant difference in Vs and Vd values between the groups before treatment (p>0.05). NDS scores in observation group were significantly lower than those in control group at 6 months and 1 year after treatment (p<0.05). There were no significant changes in NDS score at 6 and 12 months after treatment in control group compared with pretreatment group (p>0.05). NDS in observation group was significantly reduced at 6 and 12 months after treatment compared with pretreatment level (p<0.05). One year after treatment, incidence of cerebral infarction and transient ischemic attack and mortality in observation group were significantly lower than those in the control group (p<0.05). Intracranial vascular interventional therapy can achieve satisfactory outcomes in the treatment of cerebral ischemia, and can effectively promote nerve function recovery, and reduce the incidence of cerebrovascular diseases and mortality.
研究了血管介入治疗与阿司匹林联合降纤酶对大鼠脑缺血模型的治疗效果。选取90只大鼠建立脑缺血模型。将动物模型随机分为观察组和对照组，每组45只。观察组大鼠接受血管介入治疗，对照组大鼠接受阿司匹林联合降纤酶治疗。比较两组治疗12个月前后的收缩期峰值流速（Vs）和舒张末期流速（Vd）。比较治疗6个月前后、治疗12个月前后的治疗效果。治疗后观察组12个月时血管病变的Vs和Vd降低，且显著低于对照组（p<0.05）。治疗后观察组的Vs和Vd显著降低（p<0.05）。治疗前两组的Vs和Vd值无显著差异（p>0.05）。治疗后6个月和1年时观察组的神经功能缺损评分（NDS）显著低于对照组（p<0.05）。与治疗前组相比，对照组治疗后6个月和12个月时NDS评分无显著变化（p>0.05）。与治疗前水平相比，观察组治疗后6个月和12个月时NDS显著降低（p<0.05）。治疗1年后，观察组的脑梗死、短暂性脑缺血发作发生率及死亡率均显著低于对照组（p<0.05）。颅内血管介入治疗在脑缺血治疗中可取得满意疗效，能有效促进神经功能恢复，降低脑血管疾病发生率及死亡率。
