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结扎切断法在活体供肝右半肝切除术中胆管离断的应用

Ligation and cut as a method for bile duct division in living donor right hepatectomy.

作者信息

Kim Seong Hoon, Lee Eung Chang, Lee Seung Duk, Park Sang Jae

机构信息

Organ Transplantation Center, Center for Liver Cancer, National Cancer Center, Ilsandong-gu, Goyang-si Gyeonggi-do, South Korea.

出版信息

Liver Transpl. 2017 Apr;23(4):448-456. doi: 10.1002/lt.24670.

Abstract

The importance of bile duct division cannot be overemphasized in living donor surgery. Ligation and cut (LC) as a method for bile duct division in living donor right hepatectomy (LDRH) has never been reported. The purpose of this study was to introduce the LC method of bile duct division in LDRH. All LDRH donors were identified through a prospectively maintained database at the authors' institution between September 2009 and March 2013, and the 2 methods, LC and cut and oversewing (CO), were compared both in terms of donor and recipient outcomes of right lobe living donor liver transplantation. In the LC method, after complete parenchymal transection, the right hepatic duct was dissected in the Glisson's sheath and ligated just at the right side of the confluence, and then the right side of the ligature was cut. The LC and CO methods were performed in 109 and 134 donors, respectively. Bile duct division time (P < 0.001) and operative time (P < 0.001) were significantly shorter in the LC group than in the CO group. With a median follow-up of 60.2 months, biliary complication rate was lower in the LC group than in the CO group (0% versus 5.2%; P = 0.01), but with no significant difference between the recipient groups. All donors made a complete recovery. In conclusion, the bile ducts of living donors can be dissected safely from the Glisson's sheath, and the LC method facilitates bile duct division and has a lower incidence of biliary complication in LDRH without compromising the recipient outcomes. Liver Transplantation 23 448-456 2017 AASLD.

摘要

在活体供肝手术中,胆管离断的重要性无论如何强调都不为过。作为活体供肝右半肝切除术(LDRH)中胆管离断的一种方法,结扎并切断(LC)法此前从未被报道过。本研究的目的是介绍LDRH中胆管离断的LC法。通过作者所在机构前瞻性维护的数据库,确定了2009年9月至2013年3月期间所有的LDRH供体,并比较了LC法和切断并缝合(CO)法在右半肝活体供肝肝移植供体和受体结局方面的差异。在LC法中,在实质完全离断后,在肝门 Glisson鞘内解剖出右肝管,在汇合处右侧结扎,然后切断结扎线的右侧部分。分别有109例和134例供体采用了LC法和CO法。LC组的胆管离断时间(P<0.001)和手术时间(P<0.001)显著短于CO组。中位随访60.2个月时,LC组的胆道并发症发生率低于CO组(0%对5.2%;P = 0.01),但受体组之间无显著差异。所有供体均完全康复。总之,活体供体的胆管可在Glisson鞘内安全解剖,LC法便于胆管离断,且在LDRH中胆道并发症发生率较低,同时不影响受体结局。《肝脏移植》2017年第23卷448 - 456页美国肝病研究学会

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