Ciavattini Andrea, Serri Matteo, Delli Carpini Giovanni, Morini Stefano, Clemente Nicolò
a Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche , Ancona , Italy.
Gynecol Endocrinol. 2017 Feb;33(2):164-167. doi: 10.1080/09513590.2016.1239254. Epub 2016 Nov 4.
The aim of this study was to assess the vitamin D serum level in women with ovarian endometriosis; specifically, a possible correlation between the dimensions of ovarian endometriomas and vitamin D serum levels was evaluated.
This was an observational study of childbearing-age women diagnosed with singleton ovarian endometrioma from January 2015 to December 2015. Women diagnosed with multiple ovarian endometriomas or extraovarian endometriosis were excluded.
Forty-nine women constituted the initial study cohort. In these women, the mean (±SD) 25-OH-D3 serum level was 22.0 (±8.9) ng/ml, and 42 of them (85.7%) were diagnosed with hypovitaminosis D. In the "hypovitaminosis D women", the mean (± SD) diameter of ovarian endometriomas was 40.2 ± 22.6 mm, while in the "normal vitamin D serum level women" it was 26.7 ± 12.1 mm (p = 0.1). However, a significant linear correlation between 25-OH-D3 serum level and the diameter of ovarian endometriomas was found (r = -0.3, p = 0.03).
We found a relatively high rate of women with ovarian endometriosis and hypovitaminosis D. Interestingly, a significant linear correlation between 25-OH-D3 serum levels and the diameter of ovarian endometrioma emerged.
本研究旨在评估卵巢子宫内膜异位症女性的血清维生素D水平；具体而言，评估卵巢子宫内膜异位囊肿大小与血清维生素D水平之间可能存在的相关性。
这是一项对2015年1月至2015年12月诊断为单发性卵巢子宫内膜异位囊肿的育龄女性进行的观察性研究。排除诊断为多发性卵巢子宫内膜异位囊肿或卵巢外子宫内膜异位症的女性。
49名女性构成初始研究队列。这些女性的血清25-羟基维生素D3平均水平为22.0（±8.9）ng/ml，其中42名（85.7%）被诊断为维生素D缺乏症。在“维生素D缺乏症女性”中，卵巢子宫内膜异位囊肿的平均（±标准差）直径为40.2±22.6mm，而在“血清维生素D水平正常女性”中为26.7±12.1mm（p = 0.1）。然而，发现血清25-羟基维生素D3水平与卵巢子宫内膜异位囊肿直径之间存在显著线性相关性（r = -0.3，p = 0.03）。
我们发现卵巢子宫内膜异位症女性和维生素D缺乏症的发生率相对较高。有趣的是，血清25-羟基维生素D3水平与卵巢子宫内膜异位囊肿直径之间出现了显著线性相关性。
