通过层层组装制备碳纳米管纳米复合材料及其在生物医学应用中的评估。
Fabrication of carbon nanotube nanocomposites via layer-by-layer assembly and evaluation in biomedical application.
作者信息
Shao Han, Zhao Peipei, Su Lin, Tian Lingling, Zhang Yongnu, Sun Yuqiao, Yue Song, Xue Wei, Ramakrishna Seeram, He Liumin
机构信息
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, 510632, China.
Center for Nanofibers & Nanotechnology, Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore.
出版信息
Nanomedicine (Lond). 2016 Dec;11(23):3087-3101. doi: 10.2217/nnm-2016-0272. Epub 2016 Nov 4.
AIM
To investigate the influence of ion pairing of carboxylated multiwalled carbon nanotubes (MWCNT-COOH) and polycations on the layer-by-layer assembly of nanocomposites and their biocompatibility for biomedical applications.
MATERIALS & METHODS: Strong polycation poly(dimethyldiallylammonium chloride), and weak polycations chitosan and polyethyleneimine were selected to assembly with MWCNT-COOH. The MWCNT-COOH/polycation nanocomposites were analyzed by their physicochemical, electrical properties and biocompatibility.
RESULTS
The ion pairing of CNTs/polyelectrocytes played a critical role in the layer-by-layer assembly. Strong interactions between MWCNTs and poly(dimethyldiallylammonium chloride) produced thicker nanocomposites with rougher surfaces, higher MWCNT mass and better conductance. All the MWCNT multilayered nanocomposites were of good biocompatibility.
CONCLUSION
The MWCNT multilayered nanocomposites hold high potential for biomedical applications.
目的
研究羧基化多壁碳纳米管（MWCNT-COOH）与聚阳离子的离子配对对纳米复合材料逐层组装及其在生物医学应用中的生物相容性的影响。
材料与方法
选择强聚阳离子聚二甲基二烯丙基氯化铵以及弱聚阳离子壳聚糖和聚乙烯亚胺与MWCNT-COOH进行组装。通过其物理化学、电学性质和生物相容性对MWCNT-COOH/聚阳离子纳米复合材料进行分析。
结果
碳纳米管/聚电解质的离子配对在逐层组装中起关键作用。MWCNT与聚二甲基二烯丙基氯化铵之间的强相互作用产生了更厚的纳米复合材料，其表面更粗糙，MWCNT质量更高且导电性更好。所有MWCNT多层纳米复合材料均具有良好的生物相容性。
结论
MWCNT多层纳米复合材料在生物医学应用中具有很高的潜力。
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