Wairkar Sarika, Gaud Ram, Raghavan Adhithi
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, V.L.Mehta Road, Vile Parle (W), Mumbai, - 400 056, Maharashtra India.
Recent Pat Drug Deliv Formul. 2016;10(3):184-191. doi: 10.2174/1872211310666161103120006.
In the last two decades, multi-particulate dosage forms have caught the attention of formulation scientists due to their tremendous potential as a drug delivery system with a broad range of applications.
Recent patented technologies are focused on designing multi-particulate systems that can enhance therapeutic efficacy and oral bioavailability with minimum systemic toxicity. The technologies offer opportunities to the manufacturers for increasing their market share, especially for competitive generics, and also establishing intellectual property positions.
The present paper provides an overview of advanced technologies and patents, based on different principles, for designing multi-particulate dosage forms. The review covers basic characteristics of the current technologies, the mechanisms by which they overcome the limitations of conventional oral dosage forms, and their applications.
Comprehensive knowledge of these technologies will expedite further development and platform technologies for multi-particulate controlled drug delivery systems.
在过去二十年中，多颗粒剂型因其作为具有广泛应用的药物递送系统的巨大潜力而引起了制剂科学家的关注。
近期的专利技术专注于设计多颗粒系统，该系统能够以最小的全身毒性提高治疗效果和口服生物利用度。这些技术为制造商提供了增加市场份额的机会，特别是对于竞争激烈的仿制药，同时也有助于确立知识产权地位。
本文基于不同原理概述了用于设计多颗粒剂型的先进技术和专利。该综述涵盖了当前技术的基本特征、它们克服传统口服剂型局限性的机制及其应用。
对这些技术的全面了解将加速多颗粒控释药物递送系统的进一步开发和平台技术的发展。
