FMC Health and Nutrition, India Innovation Centre, FMC India Pvt. Ltd., 560052, Bangaluru, India.
Department of Chemistry, School of Advanced Sciences, VIT University, Vellore, 632014, India.
Curr Pharm Des. 2018;24(13):1349-1356. doi: 10.2174/1381612824666171204102800.
The Oral Liquid Drug Delivery System (OLDDS) remains the primary choice of dosage form, though challenging, for the pharmaceutical scientists. In the last two decades, Oral Liquid Controlled Release (OLCR) formulation has gained a lot of attention because of its advantages over the conventional dosage forms.
The world of nanotechnology has paved multiple ways to administer the drug through oral cavity in liquid dosage form with an additional advantage of control over the release. In the current study, the various approaches towards the same have been discussed comprehensively to understand the different mechanisms of OLCR.
This review also emphasizes on the existing techniques and the developments that have been made to improve on its efficacy including various formulation related factors. It also provides valuable insights into the role of polymers in the development of OLCR formulation that can be used in the management of Gastroesophageal Reflux Disease (GERD).
尽管具有挑战性，但口服液体药物递送系统（OLDDS）仍是制药科学家的主要剂型选择。在过去的二十年中，口服液体控释（OLCR）制剂因其优于传统剂型的优势而引起了广泛关注。
纳米技术领域为通过口腔以液体剂型给予药物开辟了多种途径，并且具有控制释放的额外优势。在本研究中，全面讨论了实现这一目标的各种方法，以了解 OLCR 的不同机制。
本综述还强调了现有的技术和为提高其疗效而进行的开发，包括各种制剂相关因素。它还深入了解了聚合物在开发 OLCR 制剂中的作用，这些制剂可用于治疗胃食管反流病（GERD）。
