[辐照大鼠的药物药效学特征]
[Characteristics of drug pharmacodynamics in irradiated rats].
作者信息
Khakimov Z Z
出版信息
Radiobiologiia. 1989 Jul-Aug;29(4):492-4.
PMID:2780982
Abstract
A whole-body exposure of rats to 8 Gy radiation is ineffective in 3 days, and in 6 days, it prolongs considerably the effect and increases the pharmacological activity of hexenal, meprobamate, ethylmorphine, and amidopyrine, inhibits the activity of amidopyrine demethylase, aniline hydroxylase, NADPH-cytochrome c reductase, and reduces the content of protein, cytochromes P-450 and b5 in a microsomal liver fraction.
摘要
给大鼠全身照射8 Gy辐射，3天时无效果，6天时可显著延长己醛、眠尔通、乙基吗啡和氨基比林的作用时间并增强其药理活性，抑制氨基比林脱甲基酶、苯胺羟化酶、NADPH-细胞色素c还原酶的活性，并降低肝微粒体部分蛋白质、细胞色素P-450和b5的含量。
相似文献
1
[Characteristics of drug pharmacodynamics in irradiated rats].[辐照大鼠的药物药效学特征]
Radiobiologiia. 1989 Jul-Aug;29(4):492-4.
2
3
[The state of the microsomal oxidative system in the liver of rats with acute osteomyelitis of the mandible].[下颌骨急性骨髓炎大鼠肝脏微粒体氧化系统的状态]
Vopr Med Khim. 1987 May-Jun;33(3):101-4.
4
[Effect of thiamine on the activity of liver endoplasmic reticulum enzymes metabolizing drugs].[硫胺素对肝脏内质网药物代谢酶活性的影响]
Farmakol Toksikol. 1979 Jan-Feb;42(1):56-9.
5
[Pharmacological activity of drugs in nephrectomy in rats].[大鼠肾切除术中药物的药理活性]
Farmakol Toksikol. 1983 May-Jun;46(3):108-12.
6
[Action of alpha-tocopherol on the enzymes of the electron transport chains in the liver microsomes of irradiated rats].
Radiobiologiia. 1988 May-Jun;28(3):426-9.
7
[Characteristics of the action of drugs metabolized in the liver in experimental splenectomy].[实验性脾切除术中肝脏代谢药物的作用特征]
Farmakol Toksikol. 1987 Sep-Oct;50(5):25-8.
8
9
[Functional state of the hepatocyte cytoplasmic network in rats with thermal burns].
Vopr Med Khim. 1987 Mar-Apr;33(2):48-51.
10
[Changes in testosterone oxidation in rat liver microsomes after prolonged administration of ethylmorphine].[长期给予乙基吗啡后大鼠肝脏微粒体中睾酮氧化的变化]
Biokhimiia. 1981 Feb;46(2):347-52.
Zotero 插件