[Effect of vitamin K3 on the redox chain enzyme activity of the rat liver endoplasmic network and the hydroxylation of amidopyrine, ethylmorphine and aniline].

A single subcutaneous injection of vitamin K3 into male rats activates NADP H-ferritochromo-c-oxidoreductase in membranes of hepatocyte endoplasmic reticulum. As the vitamin dose is raised up to 50 mg/kg, the function of NADP . H-nitrotetrasolium-reductases also increases. Administration of the vitamin in a dose of 70 mg/kg per os for 10 days brings about activation of NADP . H- and NADP . H-nitrotetrasolium-reductases along with an appreciable increase in the rate of N-demethylation of amidopyrine and p-hydroxylation of aniline.