Lee Sook-Hyun, van den Noort Maurits, Bosch Peggy, Lim Sabina
Department of Applied Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Research Group of Pain and Neuroscience, WHO Collaborating Center for Traditional Medicine, East-west Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea.
BMC Complement Altern Med. 2016 Nov 3;16(1):430. doi: 10.1186/s12906-016-1405-5.
Many animal experimental studies have been performed to investigate the efficacy of acupuncture in Parkinson's disease (PD). Sex differences are a major issue in all diseases including PD. However, to our knowledge, there have been no reviews investigating sex differences on the effectiveness of acupuncture treatment for animal PD models. The current study aimed to summarize and analyze past studies in order to evaluate these possible differences.
Each of 7 databases (MEDLINE, EMBASE, the Cochrane Library, 3 Korean medical databases, and the China National Knowledge Infrastructure) was searched from its inception through March 2015 without language restrictions.
We included studies of the use of acupuncture treatment in animal models of PD. A total of 810 potentially relevant articles were identified, 57 of which met our inclusion criteria. C57/BL6 mice were used most frequently (42 %) in animal PD models. Most of the studies were carried out using only male animals (67 %); only 1 study (2 %) was performed using solely females. The further 31 % of the studies used a male/female mix or did not specify the sex.
The results of our review suggest that acupuncture is an effective treatment for animal PD models, but there is insufficient evidence to determine whether sex differences exist. Future studies of acupuncture treatment for PD should use female animal models because they reflect the physiological characteristics of both males and females to fully evaluate the effect and the safety of the treatment for each sex.
许多动物实验研究已开展，以探究针刺治疗帕金森病（PD）的疗效。性别差异是包括PD在内的所有疾病中的一个主要问题。然而，据我们所知，尚无关于针刺治疗动物PD模型有效性的性别差异的综述。本研究旨在总结和分析以往研究，以评估这些可能存在的差异。
检索了7个数据库（MEDLINE、EMBASE、Cochrane图书馆、3个韩国医学数据库和中国知网）自建库起至2015年3月的数据，无语言限制。
我们纳入了针刺治疗PD动物模型的研究。共识别出810篇潜在相关文章，其中57篇符合我们的纳入标准。在动物PD模型中，C57/BL6小鼠使用最为频繁（42%）。大多数研究仅使用雄性动物进行（67%）；仅有1项研究（2%）仅使用雌性动物。另外31%的研究使用了雄性/雌性混合动物或未明确说明性别。
我们的综述结果表明，针刺是治疗动物PD模型的有效方法，但尚无足够证据确定是否存在性别差异。未来关于针刺治疗PD的研究应使用雌性动物模型，因为它们能反映雄性和雌性的生理特征，以便充分评估该治疗方法对每种性别的效果和安全性。
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