Angin Yeliz, Beauloye Christophe, Horman Sandrine, Bertrand Luc
Pole of Cardiovascular Research, Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Brussels, Belgium.
Division of Cardiology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Exp Suppl. 2016;107:23-43. doi: 10.1007/978-3-319-43589-3_2.
This chapter summarizes AMPK function in the regulation of substrate and energy metabolism with the main emphasis on carbohydrate and lipid metabolism, protein turnover, mitochondrial biogenesis, and whole-body energy homeostasis. AMPK acts as whole-body energy sensor and integrates different signaling pathway to meet both cellular and body energy requirements while inhibiting energy-consuming processes but also activating energy-producing ones. AMPK mainly promotes glucose and fatty acid catabolism, whereas it prevents protein, glycogen, and fatty acid synthesis.
本章总结了AMPK在底物和能量代谢调节中的功能，主要侧重于碳水化合物和脂质代谢、蛋白质周转、线粒体生物发生以及全身能量稳态。AMPK作为全身能量传感器，整合不同的信号通路，以满足细胞和身体的能量需求，同时抑制能量消耗过程，但也激活能量产生过程。AMPK主要促进葡萄糖和脂肪酸分解代谢，而阻止蛋白质、糖原和脂肪酸合成。
