关于头孢菌素类抗生素的药代动力学

On the pharmacokinetics of cephalosporin antibiotics.

作者信息

Andersson K E

出版信息

Scand J Infect Dis Suppl. 1978(13):37-46.

Abstract

A review is given on the pharmacokinetic characteristics of some cephalosporin antibiotics. The use of the pharmacokinetic parameters serum concentration, serum protein binding, serum half life, and apparent volume of distribution as a basis for the selection of the clinically most effective cephalosporin derivative is discussed. It is concluded that these parameters must be used in conjunction with data on tissue distribution to specialized sites, and with information on antibacterial activity and toxicity.

摘要

对一些头孢菌素类抗生素的药代动力学特征进行了综述。讨论了将药代动力学参数血清浓度、血清蛋白结合率、血清半衰期和表观分布容积作为选择临床上最有效的头孢菌素衍生物的依据。得出的结论是，这些参数必须与特定组织分布的数据以及抗菌活性和毒性信息结合使用。