Eichenwald H F, Schmitt H J
Eur J Pediatr. 1986 Apr;144(6):532-8. doi: 10.1007/BF00496029.
The cephalosporins have been available for clinical use for nearly 20 years and a large number is presently marketed, including drugs with a wide range of different pharmacokinetic and microbiologic properties. While some of these agents have certain specific uses in which they excel, the cephalosporins have not replaced older antibiotics but do provide the physician with a broader range of choices for the treatment of many infections, allowing greater individualization of therapy.
头孢菌素类药物已可供临床使用近20年,目前市面上有大量此类药物,包括具有广泛不同药代动力学和微生物学特性的药物。虽然其中一些药物在某些特定用途方面表现出色,但头孢菌素类药物并没有取代 older antibiotics(此处可能有误,推测是“老一代抗生素”),而是确实为医生在治疗许多感染时提供了更广泛的选择,使治疗能够更具个体化。