Marinho Cirlene de Lima, Maioli Maria Christina Paixão, Soares Andrea Ribeiro, Bedirian Ricardo, Melo Pedro Lopes de, Guimarães Fernando Silva, Ferreira Arthur de Sá, Lopes Agnaldo José
Post-graduate Program in Clinical and Experimental Physiopathology, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Hematology Department, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Post-graduate Program in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
J Bodyw Mov Ther. 2016 Oct;20(4):824-831. doi: 10.1016/j.jbmt.2016.02.005. Epub 2016 Feb 15.
Sickle cell anemia (SCA) is characterized by a broad spectrum of abnormalities that affect most body organs and systems. To date, there is few data on the influence of these patients' clinical characteristics on the functional exercise capacity.
To investigate the effect of the clinical complications on the functional exercise capacity of adult SCA patients.
Cross-sectional study, where 45 SCA patients underwent clinical evaluations, echocardiography, pulmonary function testing, and determination of six-minute walking distance (6MWD).
A significant correlation (P < 0.001) was found between 6MWD and hemoglobin (Hb) level, tricuspid regurgitation velocity, forced vital capacity, acute chest syndrome, and diffusing capacity for carbon monoxide. The prediction model for 6MWD explained 67% of the 6MWD variability (P < 0.001).
Hemodynamics, cardiovascular function, pulmonary function, and episodes of acute lung injury seem to impact the 6MWD in adults with SCA.
镰状细胞贫血（SCA）的特征是存在广泛的异常，这些异常会影响大多数身体器官和系统。迄今为止，关于这些患者的临床特征对功能运动能力的影响的数据很少。
研究临床并发症对成年SCA患者功能运动能力的影响。
横断面研究，45例SCA患者接受了临床评估、超声心动图检查、肺功能测试以及六分钟步行距离（6MWD）测定。
发现6MWD与血红蛋白（Hb）水平、三尖瓣反流速度、用力肺活量、急性胸综合征和一氧化碳弥散量之间存在显著相关性（P < 0.001）。6MWD的预测模型解释了6MWD变异性的67%（P < 0.001）。
血流动力学、心血管功能、肺功能和急性肺损伤发作似乎会影响成年SCA患者的6MWD。
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