Zhang Hui-Ping, Zhang Rong
Department of Otolaryngology and Head-Neck Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Department of Otolaryngology and Head-Neck Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
J Voice. 2017 May;31(3):380.e1-380.e6. doi: 10.1016/j.jvoice.2016.05.007. Epub 2016 Nov 2.
This study aims to investigate the correlations between serum apolipoprotein A-I (ApoA-I) and the formation of vocal cord polyps (VCPs).
This study used the nonmatched case-control study method.
The serum total cholesterol (TC), triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, ApoA-I, apolipoprotein B (ApoB), and ApoA-I/ApoB levels of 89 VCP patients and 87 normal volunteers were compared. Additionally, such VCP-related factors as excessive vocal use, vocal abuse, smoking, drinking, and the size of VCPs were analyzed.
The two groups did not significantly differ with regard to triglyceride, low-density lipoprotein cholesterol, ApoB, and ApoA-I/ApoB levels (P > 0.05), whereas they did significantly differ with regard to TC, HDL-C, and ApoA-I levels (P < 0.05) according to independent t tests. Logistic regression analysis showed that excessive vocal use and vocal abuse were risk factors for VCPs (P < 0.05), with odds ratio values of 5.675 and 12.781, respectively. The ApoA-I level was negatively associated with VCPs (P < 0.05), with an odds ratio of 0.511; however, TC and HDL-C were not associated with the formation of VCPs (P > 0.05). The size of VCPs in females was negatively correlated with the serum ApoA-I level (r = -0.349, P = 0.032), whereas that in males was not (P > 0.05).
As the serum ApoA-I level was negatively correlated with the formation of VCPs, ApoA-I may reduce the risk of VCPs. These findings may facilitate the prevention and treatment of VCPs.
本研究旨在探讨血清载脂蛋白A-I（ApoA-I）与声带息肉（VCPs）形成之间的相关性。
本研究采用非匹配病例对照研究方法。
比较89例VCP患者和87名正常志愿者的血清总胆固醇（TC）、甘油三酯、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇、ApoA-I、载脂蛋白B（ApoB）及ApoA-I/ApoB水平。此外，分析了过度用嗓、用嗓不当、吸烟、饮酒及VCPs大小等与VCP相关的因素。
根据独立样本t检验，两组在甘油三酯、低密度脂蛋白胆固醇、ApoB及ApoA-I/ApoB水平方面差异无统计学意义（P>0.05），而在TC、HDL-C及ApoA-I水平方面差异有统计学意义（P<0.05）。Logistic回归分析显示，过度用嗓和用嗓不当是VCPs的危险因素（P<0.05），比值比分别为5.675和12.781。ApoA-I水平与VCPs呈负相关（P<0.05），比值比为0.511；然而，TC和HDL-C与VCPs的形成无关（P>0.05）。女性VCPs大小与血清ApoA-I水平呈负相关（r=-0.349，P=0.032），而男性则无相关性（P>0.05）。
由于血清ApoA-I水平与VCPs的形成呈负相关，ApoA-I可能降低VCPs的发生风险。这些发现可能有助于VCPs的预防和治疗。
