Tursunova Iu D, Kliushnik T P, Burbaeva G Sh
Zh Nevropatol Psikhiatr Im S S Korsakova. 1989;89(5):105-8.
The concentration of water-soluble glial fibrillary acidic protein was measured in several regions of human brains (12 schizophrenic patients and 13 patients without any signs of mental disease) using ELISA technique. The content of this protein was lower in thalamus and gyrus cinguli in schizophrenics as compared to normals (p less than 0.01). The protein showed no correlation with sex, age and the terms of autopsy (5 to 7 h after death). The findings suggest that decreasing concentration of the protein might reflect the changes of its synthesis, posttranslational modifications, assembling and disassembling of glial filaments and possibly the effect of psychotropic drugs.
采用酶联免疫吸附测定（ELISA）技术，测量了12例精神分裂症患者和13例无精神疾病迹象患者的人脑几个区域中水溶性胶质纤维酸性蛋白的浓度。与正常人相比，精神分裂症患者丘脑和扣带回中该蛋白的含量较低（p<0.01）。该蛋白与性别、年龄及尸检时间（死亡后5至7小时）无关。研究结果表明，该蛋白浓度降低可能反映了其合成、翻译后修饰、胶质纤维组装和解聚的变化，也可能反映了精神药物的作用。
