Cancer and Translational Medicine Research Unit, University of Oulu, POB 5000, 90014 Oulu, Finland.
Oulu University Hospital and Medical Research Center Oulu, POB 21, 90029 Oulu, Finland.
Sci Rep. 2016 Nov 7;6:36519. doi: 10.1038/srep36519.
Deficiency of vitamin D is associated with increased risk of several types of cancer including colorectal cancer (CRC). However, factors contributing to low levels of 25-hydroxyvitamin D [25(OH)D] in CRC are not clear. Therefore, in this study serum 25(OH)D levels in 117 CRC patients and 86 controls were analyzed and correlated with the clinicopathological data including morphological subtype (serrated or conventional), quantity of tumor infiltrating immune cells, levels of systemic inflammatory markers, and disease outcome. We found that the patients had lower serum 25(OH)D levels compared to the controls. Interestingly, among the patients mismatch repair deficiency, serrated morphology, and high body mass index associated with lowest serum 25(OH)D levels. In addition, patients operated in summer or autumn had higher serum 25(OH)D levels. Furthermore, serum 25(OH)D levels inversely correlated with several systemic inflammatory markers, e.g. serum C reactive protein, but did not associate with prognosis. Mechanism leading to vitamin D deficiency in these patients are not clear but could be related to the effects of systemic inflammation. Longitudinal studies are warranted to assess vitamin D deficiency as a potential risk factor for serrated colorectal polyps and adenocarcinoma.
维生素 D 缺乏与多种癌症（包括结直肠癌）的风险增加有关。然而，导致结直肠癌患者体内 25-羟维生素 D [25(OH)D] 水平低的因素尚不清楚。因此，本研究分析了 117 例结直肠癌患者和 86 例对照者的血清 25(OH)D 水平，并将其与包括形态亚型（锯齿状或常规）、肿瘤浸润免疫细胞数量、全身性炎症标志物水平和疾病结局在内的临床病理数据相关联。我们发现，与对照组相比，患者的血清 25(OH)D 水平较低。有趣的是，在患者中，错配修复缺陷、锯齿状形态和高体重指数与最低的血清 25(OH)D 水平相关。此外，夏季或秋季手术的患者血清 25(OH)D 水平较高。此外，血清 25(OH)D 水平与几种全身性炎症标志物呈负相关，例如血清 C 反应蛋白，但与预后无关。导致这些患者维生素 D 缺乏的机制尚不清楚，但可能与全身性炎症的影响有关。需要进行纵向研究来评估维生素 D 缺乏是否是锯齿状结直肠息肉和腺癌的潜在危险因素。
