结直肠癌患者血清维生素 D 和钙水平与维生素 D 受体基因多态性的关系。
Relationship between Serum Vitamin D and Calcium Levels and Vitamin D Receptor Gene Polymorphisms in Colorectal Cancer.
机构信息
Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Cancer Metabolism and Epigenetics Unit, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
出版信息
Biomed Res Int. 2019 Aug 26;2019:8571541. doi: 10.1155/2019/8571541. eCollection 2019.
BACKGROUND
Many epidemiological studies have shown that vitamin D deficiency is associated with various types of human cancers. The biological action of vitamin D and its metabolites is mediated by the transcription factor vitamin D receptor (VDR). The gene is highly expressed in the colon and is involved in many biological functions. The aim of the current study was to assess the relationship between serum vitamin D metabolite and calcium levels with polymorphisms in normal and colorectal cancer (CRC) patients.
METHODS
Fifty Saudi CRC patients and fifty controls were enrolled in the study. The levels of total vitamin D, 25(OH)D, and calcium were measured in serum.
RESULTS
The homozygous genotype (aa) of the polymorphism (rs7975232) was found to correlate with total serum vitamin D levels of CRC patients, while the heterozygous (Tt) polymorphism (rs731236) was associated with serum calcium levels. In contrast, the and polymorphisms (rs1544410 and rs2228570, resp.) did not affect the serum levels of total vitamin D, 25-hydroxyvitamin D, and calcium.
CONCLUSION
Appropriate vitamin D levels were shown to be important in preventing the onset of CRC.
背景
许多流行病学研究表明，维生素 D 缺乏与各种人类癌症有关。维生素 D 及其代谢物的生物学作用是由转录因子维生素 D 受体 (VDR) 介导的。该基因在结肠中高度表达，并参与许多生物学功能。本研究旨在评估血清维生素 D 代谢物和钙水平与正常和结直肠癌 (CRC) 患者 基因多态性之间的关系。
方法
研究纳入了 50 名沙特 CRC 患者和 50 名对照者。测量了血清中总维生素 D、25(OH)D 和钙的水平。
结果
发现 基因多态性(rs7975232)的纯合基因型 (aa) 与 CRC 患者的总血清维生素 D 水平相关，而杂合基因型 (Tt) 多态性 (rs731236) 与血清钙水平相关。相比之下，和 多态性(rs1544410 和 rs2228570，分别)不影响总维生素 D、25-羟维生素 D 和钙的血清水平。
结论
表明适当的维生素 D 水平对预防 CRC 的发生很重要。
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