衰弱的动物模型：目前在临床研究中的应用
Animal models of frailty: current applications in clinical research.
作者信息
Kane Alice E, Hilmer Sarah N, Mach John, Mitchell Sarah J, de Cabo Rafael, Howlett Susan E
机构信息
Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.
Kolling Institute of Medical Research and Sydney Medical School, University of Sydney; Department of Clinical Pharmacology; Department of Aged Care, Royal North Shore Hospital, Sydney, NSW, Australia.
出版信息
Clin Interv Aging. 2016 Oct 26;11:1519-1529. doi: 10.2147/CIA.S105714. eCollection 2016.
The ethical, logistical, and biological complications of working with an older population of people inherently limits clinical studies of frailty. The recent development of animal models of frailty, and tools for assessing frailty in animal models provides an invaluable opportunity for frailty research. This review summarizes currently published animal models of frailty including the interleukin-10 knock-out mouse, the mouse frailty phenotype assessment tool, and the mouse clinical frailty index. It discusses both current and potential roles of these models in research into mechanisms of frailty, interventions to prevent/delay frailty, and the effect of frailty on outcomes. Finally, this review discusses some of the challenges and opportunities of translating research findings from animals to humans.
针对老年人群开展研究时，在伦理、后勤保障及生物学方面存在的复杂问题，从本质上限制了对衰弱的临床研究。衰弱动物模型以及动物模型中评估衰弱的工具的最新进展，为衰弱研究提供了宝贵机遇。本综述总结了目前已发表的衰弱动物模型，包括白细胞介素-10基因敲除小鼠、小鼠衰弱表型评估工具和小鼠临床衰弱指数。它讨论了这些模型在衰弱机制研究、预防/延缓衰弱的干预措施以及衰弱对结局的影响等方面当前及潜在的作用。最后，本综述讨论了将动物研究结果转化至人类研究过程中面临的一些挑战与机遇。
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