未活化烯烃的氧化三氟甲基化和氟代烯烃化反应
Oxidative trifluoromethylation and fluoroolefination of unactivated olefins.
作者信息
Wu Ye-Bin, Lu Guo-Ping, Yuan Tao, Xu Zhu-Bing, Wan Li, Cai Chun
机构信息
Chemical Engineering College, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing, Jiangsu, People's Republic of China.
Biotechnology and Pharmaceutical Engineering College, Nanjing Tech University, Nanjing 211816, People's Republic of China.
出版信息
Chem Commun (Camb). 2016 Nov 17;52(94):13668-13670. doi: 10.1039/c6cc08178a.
Fluorine-containing organic compounds are gaining increasing importance in medicinal chemistry. Described herein is a mild and efficient method for the radical addition of olefins with TMSCF and TMSCFR (R = COOEt or CF) to deliver various α-trifluoromethylated ketones and α-fluoroolefinated ketones.
含氟有机化合物在药物化学中越来越重要。本文描述了一种温和且高效的方法，用于烯烃与TMSCF和TMSCFR（R = COOEt或CF）进行自由基加成反应，以制备各种α-三氟甲基化酮和α-氟代烯烃化酮。
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