Zhang Shengxue, Xiao Wangchuan, Wu Jingjing, Wu Fanhong, Huang Houjin, Ma Xiaoyu, Shi Yafei, Liu Chao
School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, China.
Shanghai-Sanming Engineering Research Center of Green Fluoropharmaceutical Technology, 25 Jingdong Road, Sanming 365004, China.
Molecules. 2024 Nov 27;29(23):5622. doi: 10.3390/molecules29235622.
A novel and efficient 1,2-oxidative trifluoromethylation of olefins employing Ag(OCCFSOF) as a trifluoromethyl source is described with O as the oxidant, which provides access to a variety of valuable α-trifluoromethyl-substituted ketones. The broad substrate scope, feasibility of large-scale operation, and derivatization reactions of α-trifluoromethyl ketones demonstrate the promising utility of this protocol.
描述了一种新颖且高效的烯烃1,2-氧化三氟甲基化反应，该反应使用Ag(OCCFSOF)作为三氟甲基源，以氧气作为氧化剂，可得到多种有价值的α-三氟甲基取代的酮。α-三氟甲基酮广泛的底物范围、大规模操作的可行性以及衍生化反应证明了该方法具有广阔的应用前景。
