Zhong Jiang-Tao, Zhou Shui-Hong
Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Oncotarget. 2017 Feb 21;8(8):14133-14146. doi: 10.18632/oncotarget.13044.
Radiotherapy is now widely used as a part of multidisciplinary treatment approaches for advanced laryngeal carcinoma and preservation of laryngeal function. However, the mechanism of the radioresistance is still unclear. Some studies have revealed that the Warburg effect promotes the radioresistance of various malignant tumors, including laryngeal carcinoma. Among the regulators involved in the Warburg effect, hexokinase-II (HK-II) is a crucial glycolytic enzyme that catalyzes the first essential step of glucose metabolism. HK-II is reportedly highly expressed in some human solid carcinomas by many studies. But for laryngeal carcinoma, there is only one. Till now, no studies have directly targeted inhibited HK-II and enhanced the radiosensitivity of laryngeal carcinoma. Accumulating evidence has shown that dysregulated signaling pathways often result in HK-II overexpression. Here, we summarize recent advances in understanding the association among the Warburg effect, HK-II, and the radioresistance of laryngeal carcinoma. We speculate on the feasibility of enhancing radiosensitivity by targeted inhibiting HK-II signaling pathways in laryngeal carcinoma, which may provide a novel anticancer therapy.
放射治疗目前已广泛应用于晚期喉癌多学科治疗方法并用于保留喉功能。然而，放射抗性的机制仍不清楚。一些研究表明，瓦伯格效应促进了包括喉癌在内的各种恶性肿瘤的放射抗性。在参与瓦伯格效应的调节因子中，己糖激酶-II（HK-II）是一种关键的糖酵解酶，催化葡萄糖代谢的第一步。许多研究报道，HK-II在一些人类实体癌中高表达。但对于喉癌，只有一项研究。到目前为止，尚无研究直接靶向抑制HK-II并提高喉癌的放射敏感性。越来越多的证据表明，信号通路失调常导致HK-II过表达。在此，我们总结了在理解瓦伯格效应、HK-II与喉癌放射抗性之间关联方面的最新进展。我们推测通过靶向抑制喉癌中的HK-II信号通路来提高放射敏感性的可行性，这可能提供一种新的抗癌治疗方法。
