局部抑制巨噬细胞和平滑肌细胞增殖以抑制斑块进展。
Local Inhibition of Macrophage and Smooth Muscle Cell Proliferation to Suppress Plaque Progression.
作者信息
Sukhovershin Roman A, Toledano Furman Naama E, Tasciotti Ennio, Trachtenberg Barry H
机构信息
Houston Methodist Research Institute, Houston, Texas.
Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas.
出版信息
Methodist Debakey Cardiovasc J. 2016 Sep;12(3):141-145. doi: 10.14797/mdcj-12-3-141.
Abstract
Atherosclerosis is a complex process responsible for a major burden of cardiovascular morbidity and mortality. Macrophages and smooth muscle cells (SMCs) are abundant within atherosclerotic plaques. This review discusses the role of macrophages and SMCs in plaque progression and provides an overview of nanoparticle-based approaches and other current methods for local targeting of atherosclerotic plaques.
摘要
动脉粥样硬化是一个复杂的过程，是心血管疾病发病率和死亡率的主要负担来源。巨噬细胞和平滑肌细胞（SMC）在动脉粥样硬化斑块中大量存在。本综述讨论了巨噬细胞和SMC在斑块进展中的作用，并概述了基于纳米颗粒的方法以及目前其他针对动脉粥样硬化斑块的局部靶向方法。
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