Behavioral and Molecular Genetics of Reading-Related AM and FM Detection Thresholds.
作者信息
Bruni Matthew, Flax Judy F, Buyske Steven, Shindhelm Amber D, Witton Caroline, Brzustowicz Linda M, Bartlett Christopher W
机构信息
The Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Department of Genetics and the Human Genetics Institute of New Jersey, Rutgers The State University of New Jersey, Piscataway, NJ, USA.
出版信息
Behav Genet. 2017 Mar;47(2):193-201. doi: 10.1007/s10519-016-9821-3. Epub 2016 Nov 9.
Auditory detection thresholds for certain frequencies of both amplitude modulated (AM) and frequency modulated (FM) dynamic auditory stimuli are associated with reading in typically developing and dyslexic readers. We present the first behavioral and molecular genetic characterization of these two auditory traits. Two extant extended family datasets were given reading tasks and psychoacoustic tasks to determine FM 2 Hz and AM 20 Hz sensitivity thresholds. Univariate heritabilities were significant for both AM (h = 0.20) and FM (h = 0.29). Bayesian posterior probability of linkage (PPL) analysis found loci for AM (12q, PPL = 81 %) and FM (10p, PPL = 32 %; 20q, PPL = 65 %). Bivariate heritability analyses revealed that FM is genetically correlated with reading, while AM was not. Bivariate PPL analysis indicates that FM loci (10p, 20q) are not also associated with reading.
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