阿尔茨海默病：脑活素与纳米技术作为一种治疗策略 - Suppr

Alzheimer's disease: cerebrolysin and nanotechnology as a therapeutic strategy.

作者信息

Sharma Hari S, Muresanu Dafin F, Sharma Aruna

机构信息

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, University Hospital, Uppsala University, SE-75421 Uppsala, Sweden.

Department of Clinical Neurosciences, University of Medicine & Pharmacy, Cluj-Napoca, Romania.

出版信息

Neurodegener Dis Manag. 2016 Dec;6(6):453-456. doi: 10.2217/nmt-2016-0037. Epub 2016 Nov 9.

DOI:10.2217/nmt-2016-0037

PMID:27827552

Abstract

摘要

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Alzheimer's disease: cerebrolysin and nanotechnology as a therapeutic strategy.阿尔茨海默病：脑活素与纳米技术作为一种治疗策略

Neurodegener Dis Manag. 2016 Dec;6(6):453-456. doi: 10.2217/nmt-2016-0037. Epub 2016 Nov 9.

Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease.在阿尔茨海默病转基因模型中，脑活素通过调节淀粉样蛋白前体成熟来减少β-淀粉样蛋白的产生。

J Neurosci Res. 2006 May 15;83(7):1252-61. doi: 10.1002/jnr.20818.

Alzheimer's disease neuropathology is exacerbated following traumatic brain injury. Neuroprotection by co-administration of nanowired mesenchymal stem cells and cerebrolysin with monoclonal antibodies to amyloid beta peptide.阿尔茨海默病的神经病理学在创伤性脑损伤后加剧。纳米线间充质干细胞和脑活素与抗淀粉样β肽单克隆抗体联合给药的神经保护作用。

Prog Brain Res. 2021;265:1-97. doi: 10.1016/bs.pbr.2021.04.008. Epub 2021 Aug 12.

The neuroprotective effects of Cerebrolysin in a transgenic model of Alzheimer's disease are associated with improved behavioral performance.脑活素在阿尔茨海默病转基因模型中的神经保护作用与行为表现改善相关。

J Neural Transm (Vienna). 2003 Nov;110(11):1313-27. doi: 10.1007/s00702-003-0025-7.

Cerebrolysin reduces blood-cerebrospinal fluid barrier permeability change, brain pathology, and functional deficits following traumatic brain injury in the rat.脑活素可降低创伤性脑损伤大鼠血脑屏障通透性改变、脑病理和功能缺陷。

Ann N Y Acad Sci. 2010 Jun;1199:125-37. doi: 10.1111/j.1749-6632.2009.05329.x.

Neuroprotective Effects of Nanowired Delivery of Cerebrolysin with Mesenchymal Stem Cells and Monoclonal Antibodies to Neuronal Nitric Oxide Synthase in Brain Pathology Following Alzheimer's Disease Exacerbated by Concussive Head Injury.在脑震荡性头部损伤加重的阿尔茨海默病后的脑病理学中，纳米线递送脑活素与间充质干细胞及神经元型一氧化氮合酶单克隆抗体的神经保护作用。

Adv Neurobiol. 2023;32:139-192. doi: 10.1007/978-3-031-32997-5_4.

Co-Administration of TiO2 Nanowired Mesenchymal Stem Cells with Cerebrolysin Potentiates Neprilysin Level and Reduces Brain Pathology in Alzheimer's Disease.TiO2 纳米线间质干细胞与脑活素联合给药可增强脑啡肽酶水平并减轻阿尔茨海默病的脑病理学改变。

Mol Neurobiol. 2018 Jan;55(1):300-311. doi: 10.1007/s12035-017-0742-9.

Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease.纳米线递送脑活素并结合中性内肽酶和p- Tau抗体可在阿尔茨海默病中诱导出卓越的神经保护作用。

Prog Brain Res. 2019;245:145-200. doi: 10.1016/bs.pbr.2019.03.009. Epub 2019 Apr 2.

Nanodelivery of cerebrolysin reduces pathophysiology of Parkinson's disease.脑活素的纳米递送减轻帕金森病的病理生理学。

Prog Brain Res. 2019;245:201-246. doi: 10.1016/bs.pbr.2019.03.014. Epub 2019 Apr 2.

Cerebrolysin in Alzheimer's disease.脑活素治疗阿尔茨海默病

Drugs Today (Barc). 2011 Jul;47(7):487-513. doi: 10.1358/dot.2011.47.7.1656496.

引用本文的文献

Nanowired Delivery of Curcumin Attenuates Methamphetamine Neurotoxicity and Elevates Levels of Dopamine and Brain-Derived Neurotrophic Factor.纳米递药姜黄素减轻甲基苯丙胺神经毒性并提高多巴胺和脑源性神经营养因子水平。

Adv Neurobiol. 2023;32:385-416. doi: 10.1007/978-3-031-32997-5_10.

TiO-Nanowired Delivery of Chinese Extract of Ginkgo biloba EGb-761 and Bilobalide BN-52021 Enhanced Neuroprotective Effects of Cerebrolysin Following Spinal Cord Injury at Cold Environment.低温环境下脊髓损伤后，银杏叶提取物 EGb-761 与白果内酯 BN-52021 的中药提取物的 TiO2 纳米递药系统增强了脑活素的神经保护作用。

Adv Neurobiol. 2023;32:353-384. doi: 10.1007/978-3-031-32997-5_9.

Adv Neurobiol. 2023;32:139-192. doi: 10.1007/978-3-031-32997-5_4.

Co-administration of Nanowired DL-3-n-Butylphthalide (DL-NBP) Together with Mesenchymal Stem Cells, Monoclonal Antibodies to Alpha Synuclein and TDP-43 (TAR DNA-Binding Protein 43) Enhance Superior Neuroprotection in Parkinson's Disease Following Concussive Head Injury.纳米载体 DL-3-正丁基苯酞（DL-NBP）与间充质干细胞、抗α-突触核蛋白和 TDP-43（TAR DNA 结合蛋白 43）单克隆抗体联合应用可增强创伤性脑损伤后帕金森病的卓越神经保护作用。

Adv Neurobiol. 2023;32:97-138. doi: 10.1007/978-3-031-32997-5_3.

CH(II), a cerebroprotein hydrolysate, exhibits potential neuro-protective effect on Alzheimer's disease.脑蛋白水解物（CH(II)）对阿尔茨海默病具有潜在的神经保护作用。

PLoS One. 2019 Sep 23;14(9):e0222757. doi: 10.1371/journal.pone.0222757. eCollection 2019.

Histamine H3 Inverse Agonist BF 2649 or Antagonist with Partial H4 Agonist Activity Clobenpropit Reduces Amyloid Beta Peptide-Induced Brain Pathology in Alzheimer's Disease.组胺 H3 反向激动剂 BF 2649 或具有部分 H4 激动剂活性的拮抗剂氯苯丙胺可减少阿尔茨海默病中淀粉样β肽诱导的脑病理学。

Mol Neurobiol. 2018 Jan;55(1):312-321. doi: 10.1007/s12035-017-0743-8.

Mol Neurobiol. 2018 Jan;55(1):300-311. doi: 10.1007/s12035-017-0742-9.

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Alzheimer's disease: cerebrolysin and nanotechnology as a therapeutic strategy.

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