Wexler D B, Jiang J, Gray S D, Titze I R
Department of Otolaryngology-Head and Neck Surgery, University of Iowa College of Medicine, Iowa City.
Ann Otol Rhinol Laryngol. 1989 Sep;98(9):668-73. doi: 10.1177/000348948909800902.
Damage to the vocal cords can result in scarring and impaired vibration and can manifest clinically as hoarseness and loss of vocal power. If the vibratory characteristics could be restored in these scarred vocal cords, the vocal intensity and efficiency of phonation also should improve. In an effort to enhance the vibration of damaged vocal cords, we implanted a submucosal fat autograft within the injured vocal cord cover layer of dogs 6 weeks after unilateral mucosal excision had been performed. Three months postoperatively these animals were compared to normal dogs and those with mucosal excision but no fat-grafting. Acoustic and biomechanical measures of phonation were collected from an excised larynx preparation. We found that the fat-augmented vocal cords had lower threshold pressures for phonation, greater vocal intensity, and more efficient acoustic output than injured vocal cords without the fat-grafting. These results provide a foundation for further research on reconstructive surgery of damaged vocal cords.
声带损伤可导致瘢痕形成和振动受损，并可在临床上表现为声音嘶哑和发声能力丧失。如果这些瘢痕化的声带的振动特性能够恢复，发声强度和发声效率也应会提高。为了增强受损声带的振动，我们在单侧黏膜切除术后6周，将自体黏膜下脂肪植入犬类受伤声带的覆盖层内。术后三个月，将这些动物与正常犬以及进行了黏膜切除但未进行脂肪移植的犬进行比较。从切除的喉部标本中收集发声的声学和生物力学指标。我们发现，与未进行脂肪移植的受伤声带相比，脂肪增强的声带发声阈值压力更低、发声强度更大且声学输出更高效。这些结果为进一步研究受损声带的重建手术奠定了基础。
