Klicpera C, Strian F
Pharmakopsychiatr Neuropsychopharmakol. 1978 May;11(3):113-20. doi: 10.1055/s-0028-1094569.
The anxiolytic and sedative properties of a thienodiazepine (clotiazepam) were investigated in 40 healthy subjects with varying degrees of arousal and with the aid of specific anxiety-inducing conditions. A cross-over design with a double blind technique was used. EEG, heart and respiratory rate, peripheral pulse volume and skin resistance were measured during the anxiety-inducing conditions with the visualization of neutral and fearful situations as well as with the threat of shock. The mood, physical sensations and behaviour tendencies of the test subjects were determined by self-rating questionnaires. The anxiolytic and sedative effects of the thienodiazepine under study were able to be differentiated as far as subjective perception and autonomic responses were concerned. The development of sedative and anxiolytic effects is dependent on the subject's state of arousal. Situations involving the anticipation of anxiety are sufficient as proof of pharmacogenic anxiolysis. The tranquilizer reduces anxiety and physical tension, but does not influence the timing of autonomic readiness responses, and thus does not affect the coping strategies.
在40名具有不同程度觉醒水平的健康受试者中，借助特定的诱发焦虑条件，对一种噻吩二氮䓬（氯噻西泮）的抗焦虑和镇静特性进行了研究。采用了双盲技术的交叉设计。在诱发焦虑的条件下，通过呈现中性和恐惧情境以及电击威胁，测量脑电图、心率和呼吸频率、外周脉搏容积和皮肤电阻。通过自评问卷确定受试对象的情绪、身体感觉和行为倾向。就主观感知和自主反应而言，所研究的噻吩二氮䓬的抗焦虑和镇静作用能够被区分出来。镇静和抗焦虑作用的产生取决于受试者的觉醒状态。涉及焦虑预期的情境足以证明药物性抗焦虑作用。这种镇静剂可减轻焦虑和身体紧张，但不影响自主准备反应的时机，因此不影响应对策略。
