Brito Fernanda Freitas de, Martelli Antonio Carlos Ceribelli, Cavalcante Maria Lopes Lamenha Lins, Pinto Ana Cecília Versiani Duarte, Itimura Gabriela, Soares Cleverson Teixeira
Instituto Lauro de Souza Lima (ILSL) - Bauru (SP), Brazil.
An Bras Dermatol. 2016 Sep-Oct;91(5):646-648. doi: 10.1590/abd1806-4841.20164778.
Eosinophilic pustular folliculitis (EPF) or Ofuji disease is a rare dermatosis, prone to recurrence and chronicity. The peak incidence occurs in the third decade of life and its exact etiology remains unknown. Evidence suggests that the expression of adhesion molecules and the production of cytokines activate the follicular unit, but the stimulus that triggers these changes remains unclear. The three clinical variants reported in the literature include classic EPF, immunosuppression-associated EPF, and infancy-associated EPF. We report a case of eosinophilic pustular folliculitis with peculiar epidemiological characteristics, which represents a challenging therapeutic scenario.
嗜酸性脓疱性毛囊炎（EPF）或小藤病是一种罕见的皮肤病，易于复发且病程呈慢性。发病高峰出现在生命的第三个十年，其确切病因尚不清楚。有证据表明，黏附分子的表达和细胞因子的产生激活了毛囊单位，但引发这些变化的刺激因素仍不清楚。文献报道的三种临床变体包括经典EPF、免疫抑制相关EPF和婴儿期相关EPF。我们报告了一例具有特殊流行病学特征的嗜酸性脓疱性毛囊炎病例，这代表了一个具有挑战性的治疗情况。
