Monastirli Alexandra, Antoniades George, Kapranos Nikiforos, Pasmatzi Efstathia, Badavanis George, Tsambaos Dionysios
Department of Dermatology, School of Medicine, University of Patras, Rio-Patras, Greece, Center for Dermatologic Diseases, Limassol, Cyprus.
Dermatol Online J. 2017 Nov 15;23(11):13030/qt9604k2jm.
Eosinophilic pustular folliculitis (EPF) is a rare noninfectious pruritic dermatosis, first described by Ise and Ofuji in 1965. We report the case of a 15-year oldimmunocompetent girl that presented with a widespread papulopustular eruption four days after her arrival in Japan. The clinical diagnosis of the classicform of EPF was confirmed by histological examination of the lesional skin that revealed an intense, mainly eosinophilic, dermal infiltrate within and aroundpilosebaceous units. Oral administration of lowdose indomethacin (25 mg/day) led to a complete resolution of the eruption within 6 weeks without causing any side effects. The patient is presently completing a 15-month follow-up and remains free ofrelapses. To the best of our knowledge, it is the first time that low-dose oral indomethacin is reported to be capable of causing a rapid and complete resolutionof the classic form of EPF.
嗜酸性脓疱性毛囊炎（EPF）是一种罕见的非感染性瘙痒性皮肤病，于1965年由伊势和小藤首次描述。我们报告了一例15岁免疫功能正常的女孩病例，她在抵达日本四天后出现广泛的丘疹脓疱性皮疹。通过对皮损进行组织学检查，发现毛囊皮脂腺单位内及周围有密集的、主要为嗜酸性的真皮浸润，从而确诊为经典型EPF。口服低剂量吲哚美辛（25毫克/天）导致皮疹在6周内完全消退，且未引起任何副作用。该患者目前正在完成15个月的随访，且未复发。据我们所知，这是首次报道低剂量口服吲哚美辛能够使经典型EPF迅速完全消退。
