Hokita S, Takao S, Tokushige M, Maenohara S, Aikou T, Shimazu H
First Dept. of Surgery, Kagoshima University School of Medicine.
Gan To Kagaku Ryoho. 1989 Aug;16(8 Pt 2):2901-4.
Two-route chemotherapy (TRC) with intraarterial infusion of cis-diamminedichloroplatinum and intravenous infusion of sodium thiosulfate was carried out on 8 cases of digestive cancer with liver metastases, using totally implanted injection port system. The metastases occurred from gastric cancer in 3 cases and from colonic cancer in 5 cases. Computed tomography and/or ultra-sonography revealed an overall response rate of 50% (4/8). Complete response (CR) was obtained in two cases. The therapy was repeated 12 times in one case of gastric cancer with multiple liver metastases and 5 times in another rectal cancer with a solid metastatic tumor. In the latter case, a right hepatic lobectomy was performed thereafter. The histology of the hepatic tumor showed mucin lakes and necrotic lesions, and no viable cancer cells were observed. This mode of chemotherapy was therefore considered a useful measure for the treatment of liver metastases derived from digestive cancers. Furthermore, no serious side effects occurred.
采用全植入式注射端口系统，对8例伴有肝转移的消化道癌患者进行了顺二氯二氨铂动脉内灌注和硫代硫酸钠静脉内灌注的双途径化疗（TRC）。转移瘤来自3例胃癌和5例结肠癌。计算机断层扫描和/或超声检查显示总缓解率为50%（4/8）。2例获得完全缓解（CR）。1例多发肝转移的胃癌患者进行了12次治疗，另1例有实性转移瘤的直肠癌患者进行了5次治疗。在后一例患者中，随后进行了右肝叶切除术。肝肿瘤组织学显示有黏液湖和坏死灶，未观察到存活的癌细胞。因此，这种化疗方式被认为是治疗消化道癌肝转移的一种有效措施。此外，未出现严重副作用。
