Peng Ji-Ren, Lu Ting-Ting, Chang Hao-Teng, Ge Xuan, Huang Bian, Li Wei-Min
Department of Cardiology Medicine, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
Department of Science Education, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
Biomed Res Int. 2016;2016:3708905. doi: 10.1155/2016/3708905. Epub 2016 Oct 17.
. To measure plasma levels of superoxide dismutases 1, 2, and 3 (SOD1, 2, 3) and determine whether SODs can function as biomarkers for coronary artery disease (CAD). . Patient groups were as follows: patients with stable angina pectoris (SAP, = 33), patients with acute coronary syndrome (ACS, = 49), and controls ( = 42). Protein quantification was done using ELISA. . The concentrations of plasma SOD1 and SOD2 were higher in CAD than in healthy controls. No difference in SOD3 levels between CAD and control groups was found. Limited correlations were found between SODs and gender, age, and severity of coronary artery stenosis. . Plasma levels of SOD1 and SOD2 were elevated in patients with CAD and might serve as surrogate biomarkers for CAD.
测量超氧化物歧化酶1、2和3（SOD1、2、3）的血浆水平，并确定超氧化物歧化酶是否可作为冠状动脉疾病（CAD）的生物标志物。患者组如下：稳定型心绞痛（SAP，n = 33）患者、急性冠状动脉综合征（ACS，n = 49）患者和对照组（n = 42）。使用酶联免疫吸附测定法进行蛋白质定量。CAD患者血浆SOD1和SOD2的浓度高于健康对照组。未发现CAD组和对照组之间SOD3水平存在差异。超氧化物歧化酶与性别、年龄和冠状动脉狭窄严重程度之间的相关性有限。CAD患者血浆SOD1和SOD2水平升高，可能作为CAD的替代生物标志物。
Ann Clin Lab Sci. 2018-7
Front Cardiovasc Med. 2024-10-14
Int J Mol Sci. 2024-10-10
Indian J Otolaryngol Head Neck Surg. 2023-12
Antioxidants (Basel). 2023-5-31
Eur Heart J. 2014-11-7
Biomed Environ Sci. 2014-7
Biochem Cell Biol. 2013-5-30
Rev Panam Salud Publica. 2012-4
Recent Pat Cardiovasc Drug Discov. 2012-4
Zotero 插件