Department of Orthopedic Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.
Department of Electrotheropy, Shenyang Medical College Affiliated Central Hospital, Shenyang, Liaoning, People's Republic of China.
Sci Rep. 2016 Nov 10;6:37062. doi: 10.1038/srep37062.
Osteosarcoma, the most common primary malignant bone tumor, usually arises in the metaphysis of long bones. Amplification and mutation of the epidermal growth factor receptor (EGFR) gene represent signature genetic abnormalities encountered in osteosarcoma. Noscapine is a benzylisoquinoline alkaloid derived from the opium poppy Papaver somniferum. Recently several studies have suggested its anti-cancer effect in melanoma, ovarian cancer, gliomas, breast cancer, lung cancer, and colon cancer. However, the underlying molecular mechanism for its anti-cancer effect still remains unclear. In this paper, we found the mechanism of noscapine effectively suppressed proliferation and invasion of MG63 cell line by inhibiting the phosphorylation of EGFR and its downstream pathway.
骨肉瘤是最常见的原发性恶性骨肿瘤，通常发生在长骨的干骺端。表皮生长因子受体 (EGFR) 基因的扩增和突变是骨肉瘤中遇到的标志性遗传异常。北美黄连碱是一种苯并异喹啉生物碱，来源于罂粟 Papaver somniferum。最近的几项研究表明，它在黑色素瘤、卵巢癌、神经胶质瘤、乳腺癌、肺癌和结肠癌中具有抗癌作用。然而，其抗癌作用的潜在分子机制尚不清楚。在本文中，我们发现北美黄连碱通过抑制 EGFR 及其下游途径的磷酸化，有效地抑制了 MG63 细胞系的增殖和侵袭。
