Ma Q-Q, Yang X-J, Yang N-Q, Liu L, Li X-D, Zhu K, Fu Q, Wei P
Department of Rheumatology, Xuzhou Central Hospital, Xuzhou, Jiangsu Province, P.R. China.
Eur Rev Med Pharmacol Sci. 2016 Oct;20(20):4294-4298.
We evaluated uric acid (UA) and high-sensitivity C-reactive protein (hs-CRP) levels in different clinical types of acute coronary syndromes (ACS) and in relationship with the severity of coronary artery lesions. Furthermore, we explored its clinical significance.
From June 2013 to January 2015, we studied patients in their first onset of symptoms and hospitalization for coronary angiography. According to coronary angiography results, we divided patients into two groups: 93 patients with ACS and 30 patients with normal coronary arteries as the control group. ACS patients were divided further into three subgroups: patients with ST-segment elevation myocardial infarction (STEMI) (n=34); patients with non-ST segment elevation myocardial infarction (NSTEMI) (n=29); and patients with unstable angina (n=30). According to their Gensini scores, patients were divided into mild, moderate and severe groups. We compared UA and hs-CRP levels and the relationship with Gensini scores between different groups.
UA and hs-CRP levels in the ACS group were higher than those in the control group (p < 0.05). UA and hs-CRP levels in the STEMI group were higher than those in the NSTEMI, unstable angina and control groups (p < 0.05). UA and hs-CRP levels in the NSTEMI patients were higher than those in the unstable angina and control groups (p < 0.05). UA and hs-CRP levels in the unstable angina patients were higher than those in the control group (p < 0.05). hs-CRP levels in the STEMI patients were higher than the other groups (p < 0.05). hs-CRP levels in the NSTEMI patients were higher than the unstable angina and the control groups (p < 0.05) while hs-CRP levels in the unstable angina patients were higher than the control group (p < 0.05). Additionally, according to the Gensini score group, we discovered that ACS patients in the severe group had higher hs-CRP levels than the other three groups (p < 0.05) while the moderate group had higher levels than the other two groups (p < 0.05). The mild group had higher levels than the control group (p < 0.05). Correlation analysis suggested that UA levels and Gensini scores had a positive correlation (p < 0.05). hs-CRP levels and Gensini scores also showed a positive correlation (p < 0.05).
UA and hs-CRP levels should be considered as factors to use in the risk stratification in ACS patients.
我们评估了不同临床类型急性冠状动脉综合征（ACS）患者的尿酸（UA）和高敏C反应蛋白（hs-CRP）水平，并探讨了其与冠状动脉病变严重程度的关系。此外，我们还探究了其临床意义。
2013年6月至2015年1月，我们对首次出现症状并因冠状动脉造影住院的患者进行了研究。根据冠状动脉造影结果，我们将患者分为两组：93例ACS患者和30例冠状动脉正常患者作为对照组。ACS患者进一步分为三个亚组：ST段抬高型心肌梗死（STEMI）患者（n = 34）；非ST段抬高型心肌梗死（NSTEMI）患者（n = 29）；不稳定型心绞痛患者（n = 30）。根据Gensini评分，将患者分为轻度、中度和重度组。我们比较了不同组之间的UA和hs-CRP水平以及与Gensini评分的关系。
ACS组的UA和hs-CRP水平高于对照组（p < 0.05）。STEMI组的UA和hs-CRP水平高于NSTEMI组、不稳定型心绞痛组和对照组（p < 0.05）。NSTEMI患者的UA和hs-CRP水平高于不稳定型心绞痛组和对照组（p < 0.05）。不稳定型心绞痛患者的UA和hs-CRP水平高于对照组（p < 0.05）。STEMI患者的hs-CRP水平高于其他组（p < 0.05）。NSTEMI患者的hs-CRP水平高于不稳定型心绞痛组和对照组（p < 0.05），而不稳定型心绞痛患者的hs-CRP水平高于对照组（p < 0.05）。此外，根据Gensini评分分组，我们发现重度组的ACS患者hs-CRP水平高于其他三组（p < 0.05），中度组高于其他两组（p < 0.05）。轻度组高于对照组（p < 0.05）。相关性分析表明，UA水平与Gensini评分呈正相关（p < 0.05）。hs-CRP水平与Gensini评分也呈正相关（p < 0.05）。
UA和hs-CRP水平应被视为ACS患者风险分层的因素。
