年龄相关性黄斑变性患者血清褪黑素与6-硫酸褪黑素水平的相关性

Correlation between serum melatonin and aMT6S level for age-related macular degeneration patients.

作者信息

Lv X-D, Liu S, Cao Z, Gong L-L, Feng X-P, Gao Q-F, Wang J, Hu L, Cheng X-C, Yu C-H, Xing Y-Q

机构信息

Eye Center, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.

出版信息

Eur Rev Med Pharmacol Sci. 2016 Oct;20(20):4196-4201.

PMID:27831657

Abstract

OBJECTIVE

To analyze the levels of serum melatonin (MLT) and assay of 6-sulfatoxymelatonin (aMT6S) of age-related macular degeneration (AMD) patients and study their correlation with AMD risk factors.

PATIENTS AND METHODS

58 AMD cases were selected and 58 healthy cases of the same time period were selected according to 1:1 closest matching method. ELISA method was used to test serum MLT and aMT6S level.

RESULTS

Levels of MLT and aMT6S in AMD group were lower than those in the control group, and differences were statistically significant (p < 0.05). Based on analysis of AMD subgroup, differences on gender had no statistical significance compared with AMD type. For cases with smoking, cardiovascular disease and corrected visual acuity lower than 0.1, MLT and aMT6S levels were reduced at 0.05). Through the regression analysis, we concluded that smoking history, cardiovascular disease history, best corrected visual acuity, MLT and aMT6S level were independent risk factors, among which MLT [OR = 3.624 (odds ratio: OR)] and aMT6S (OR = 3.201).

CONCLUSIONS

MLT and aMT6S may be related to the incidence of AMD.

摘要

目的

分析年龄相关性黄斑变性（AMD）患者血清褪黑素（MLT）水平及6-硫酸氧褪黑素（aMT6S）含量，并研究它们与AMD危险因素的相关性。

患者与方法

选取58例AMD患者，并按照1:1最接近匹配法选取同期58例健康对照者。采用酶联免疫吸附测定（ELISA）法检测血清MLT和aMT6S水平。

结果

AMD组MLT和aMT6S水平低于对照组，差异有统计学意义（p<0.05）。基于AMD亚组分析，性别差异与AMD类型相比无统计学意义。对于吸烟、患有心血管疾病及矫正视力低于0.1的患者，MLT和aMT6S水平降低（p<0.05）。通过回归分析得出，吸烟史、心血管疾病史、最佳矫正视力、MLT和aMT6S水平为独立危险因素，其中MLT[比值比（OR）=3.624]和aMT6S（OR=3.201）。