Crasson M, Kjiri S, Colin A, Kjiri K, L'Hermite-Baleriaux M, Ansseau M, Legros J J
Psychoneuroendocrinology Unit, Service d'Endocrinologie, Université de Liège, B-35, CHU, B-4000, Liège, Belgium.
Psychoneuroendocrinology. 2004 Jan;29(1):1-12. doi: 10.1016/s0306-4530(02)00123-3.
In this study, serum melatonin and urinary 6-sulfatoxymelatonin (aMT6s) were measured in 14 major depressive inpatients, compared to 14 matched controls according to age, gender, season and hormonal treatment in women. Moreover, the relationship between serum melatonin and urinary aMT6s levels was analysed in the two groups. Results indicated that the two groups of subjects showed a clear melatonin rhythm without significant difference in the mean level of melatonin or aMT6s, in the area under the curve of melatonin or in the melatonin peak. However, the time of the nocturnal melatonin peak secretion was significantly delayed in depressive subjects as compared to healthy controls. Moreover, the depressed patients showed urinary aMT6s concentrations enhanced in the morning compared to night time levels, while these concentrations were lowered from the night to the morning in the control group. These results suggest that the melatonin production is phase-shifted in major depression.
在本研究中，对14名重度抑郁住院患者测定了血清褪黑素和尿6-硫酸氧褪黑素（aMT6s），并与14名根据年龄、性别、季节和女性激素治疗情况匹配的对照组进行比较。此外，分析了两组中血清褪黑素与尿aMT6s水平之间的关系。结果表明，两组受试者均呈现出明显的褪黑素节律，褪黑素或aMT6s的平均水平、褪黑素曲线下面积或褪黑素峰值均无显著差异。然而，与健康对照组相比，抑郁受试者夜间褪黑素峰值分泌时间显著延迟。此外，与夜间水平相比，抑郁患者早晨尿aMT6s浓度升高，而对照组这些浓度从夜间到早晨降低。这些结果表明，重度抑郁症患者的褪黑素分泌相位发生了改变。
