Alvarez N
Wrentham State School, MA 02093.
Am J Ment Retard. 1989 May;93(6):593-9.
Fifty patients with developmental disabilities and past history of epilepsy but without reported seizures fo several years underwent trial reductions of an antiepileptic drug. After an 8-year follow-up there was recurrence of seizures in 26 patients. Predictors for a seizure free state off medication were: few documented seizures in lifetime, no gross neurological abnormalities, medication below therapeutic levels at time of discontinuance, and persistently normal EEGs before and after discontinuance. Successful withdrawal of medication may have resulted from early control of seizures or early treatment; lack of actual epileptic seizures but presence of "pseudoseizures"; isolated event seizures; or seizures that could have resulted from nonepileptic, self-limiting factors.
五十名有发育障碍且有癫痫病史但数年未报告发作的患者接受了抗癫痫药物的减量试验。经过8年的随访，26名患者出现了癫痫复发。停药后无癫痫发作状态的预测因素为：一生中记录的发作次数少、无明显神经学异常、停药时药物低于治疗水平以及停药前后脑电图持续正常。成功停药可能是由于癫痫发作的早期控制或早期治疗；无实际癫痫发作但存在“假性发作”；孤立性发作；或可能由非癫痫性、自限性因素导致的发作。
