Marcus J C
Division of Child Neurology, SUNY-Health Sciences Center at Brooklyn 11203, USA.
Neuropediatrics. 1998 Feb;29(1):26-8. doi: 10.1055/s-2007-973529.
It has, increasingly, become the practice to withdraw antiepileptic drugs (AEDs) in epileptic patients, who have been seizure-free for two years. However, the presence of mental retardation is frequently considered to be a markedly adverse factor for stopping treatment. Many physicians are loth to phase out AEDs in mentally retarded patients. In this study, 29 well-controlled epileptic, mentally-retarded children had their AEDs withdrawn. Seventeen have remained well and 12 have relapsed. IQ, neurological findings, EEGs, types of epilepsy, frequency of attacks, age of onset, duration of the active disease and the fit-free period, and antiepileptic drug (AED) levels did not predict the outcome. It is suggested that consideration be given to withdrawing AEDs from well-controlled, mentally-retarded, epileptic children.
在癫痫患者中，越来越多地出现了在已无癫痫发作两年的情况下停用抗癫痫药物（AEDs）的做法。然而，智力迟钝的存在常常被视为停药的一个明显不利因素。许多医生不愿意在智力迟钝的患者中逐步停用AEDs。在本研究中，29名病情得到良好控制的癫痫智力迟钝儿童停用了AEDs。17名儿童仍情况良好，12名儿童复发。智商、神经学检查结果、脑电图、癫痫类型、发作频率、发病年龄、活动性疾病持续时间和无癫痫发作期，以及抗癫痫药物（AED）水平均无法预测结果。建议考虑在病情得到良好控制的癫痫智力迟钝儿童中停用AEDs。
