Xie X, Shi X, Xun X, Rao L
Department of Cardiology, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
Division of Reproductive Medical Center, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
Herz. 2017 Sep;42(6):593-603. doi: 10.1007/s00059-016-4495-4. Epub 2016 Nov 10.
The association between microRNA polymorphisms (miR polymorphisms) and coronary heart disease (CHD) risk has been studied intensively, but the results have been conflicting. Therefore, we conducted the present meta-analysis to obtain a more conclusive answer. We searched for eligible articles in PubMed, MEDLINE, EMBASE, Scopus, and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to identify any potential associations. Ten case-control studies including 5,292 CHD patients and 5,446 control subjects were analyzed. The overall meta-analysis results showed that the miR-146a rs2910164 polymorphism, the miR-196a2 rs11614913 polymorphism, and the miR-499 rs3746444 polymorphism were all significantly associated with CHD risk in certain genetic models. Besides, the C allele of the miR-146a rs2910164 and miR-499 rs3746444 polymorphisms conferred increased susceptibility to CHD (C versus G, p < 0.0001, OR = 1.14, 95% CI = 1.07-1.21; p = 0.003, OR = 1.14, 95% CI = 1.05-1.25). Overall, our findings suggest that the miR-146a rs2910164, miR-196a2 rs11614913, and miR-499 rs3746444 polymorphisms may be correlated with the risk of CHD.
微小RNA多态性（miR多态性）与冠心病（CHD）风险之间的关联已得到深入研究，但结果相互矛盾。因此，我们进行了本次荟萃分析以获得更具结论性的答案。我们在PubMed、MEDLINE、EMBASE、Scopus和中国知网中搜索符合条件的文章。采用优势比（OR）和95%置信区间（CI）来确定任何潜在关联。对10项病例对照研究进行了分析，包括5292例冠心病患者和5446例对照受试者。总体荟萃分析结果表明，在某些遗传模型中，miR - 146a rs2910164多态性、miR - 196a2 rs11614913多态性和miR - 499 rs3746444多态性均与冠心病风险显著相关。此外，miR - 146a rs2910164和miR - 499 rs3746444多态性的C等位基因使患冠心病的易感性增加（C对G，p < 0.0001，OR = 1.14，95% CI = 1.07 - 1.21；p = 0.003，OR = 1.14，95% CI = 1.05 - 1.25）。总体而言，我们的研究结果表明，miR - 146a rs2910164、miR - 196a2 rs11614913和miR - 499 rs3746444多态性可能与冠心病风险相关。
