Department of Biomedical Science, College of Life Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, South Korea.
Department of Neurology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, 13496, South Korea.
J Thromb Thrombolysis. 2019 Feb;47(2):255-262. doi: 10.1007/s11239-018-1778-z.
Despite much progress in microRNA (miRNA) research, information regarding the association between miRNAs and venous thromboembolism (VTE), especially in Asian patients, remains limited. This case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the miRNAs miR-146a, miR-149, miR-196a2, miR-499, and VTE in Korean patients. We observed no statistically significant differences in the genotype frequency of miRNA polymorphisms between 300 control individuals and 203 VTE patients. However, we observed a significant association between three allelic combinations of miRNA polymorphisms and VTE risk. Overall, our findings suggest that specific miRNA polymorphisms are associated with the risk of VTE in a Korean population.
尽管在 microRNA（miRNA）研究方面取得了很大进展，但有关 miRNA 与静脉血栓栓塞症（VTE）之间的关联的信息，特别是在亚洲患者中，仍然有限。这项病例对照研究旨在确定在韩国患者中，编码 miRNA miR-146a、miR-149、miR-196a2、miR-499 的基因中的多态性与 VTE 之间的相关性。我们观察到在 300 名对照个体和 203 名 VTE 患者之间，miRNA 多态性的基因型频率没有统计学上的显著差异。然而，我们观察到 miRNA 多态性的三个等位基因组合与 VTE 风险之间存在显著关联。总的来说，我们的研究结果表明，特定的 miRNA 多态性与韩国人群中 VTE 的风险相关。
