神经血管单元与糖尿病视网膜病变的病理生理基础
The neurovascular unit and the pathophysiologic basis of diabetic retinopathy.
作者信息
Gardner Thomas W, Davila Jose R
机构信息
Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan Medical School, 1000 Wall St, Ann Arbor, MI, 48105, USA.
出版信息
Graefes Arch Clin Exp Ophthalmol. 2017 Jan;255(1):1-6. doi: 10.1007/s00417-016-3548-y. Epub 2016 Nov 10.
Abstract
PURPOSE
To relate the concept of the retinal neurovascular unit and its alterations in diabetes to the pathophysiology of diabetic retinopathy.
METHODS
Case illustrations and conceptual frameworks are presented that illustrate adaptive and maladaptive "dis-integration" of the retinal neurovascular unit with the progression of diabetes.
RESULTS
Retinopathy treatment should address pathophysiologic processes rather than pathologic lesions as is current practice.
CONCLUSIONS
Future improvements in the treatment of diabetic retinopathy requires deeper understanding of the cellular and molecular changes induced by diabetes, coupled with the use of quantitative phenotyping methods that assess the pathophysiologic processes.
摘要
目的
将视网膜神经血管单元的概念及其在糖尿病中的改变与糖尿病视网膜病变的病理生理学联系起来。
方法
展示病例插图和概念框架，以说明随着糖尿病进展视网膜神经血管单元的适应性和适应不良性“解体”。
结果
视网膜病变的治疗应针对病理生理过程，而不是像目前的做法那样针对病理病变。
结论
糖尿病视网膜病变治疗的未来改进需要更深入地了解糖尿病引起的细胞和分子变化，同时使用评估病理生理过程的定量表型分析方法。
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