Wang Hanqing, Chen Li, Zhang Liming, Gao Xiaojuan, Wang Yinghua, Weiwei Tao
College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, Ningxia 750004, PR China.
College of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, Ningxia 750004, PR China.
Biomed Pharmacother. 2016 Dec;84:1617-1622. doi: 10.1016/j.biopha.2016.10.113. Epub 2016 Nov 7.
The present study was designed to investigate the protective effect of Sophoraflavanone G (SG) on streptozotocin (STZ)-induced diabetic rats. The rats were intraperitoneally injected with STZ (35mg/kg). 7days later, the rats were intragastrically administered with Metformin (MET, 150mg/kg), SG (20mg/kg) or SG (40mg/kg) once daily for consecutive 30 days. The animals were anaesthetized, the blood and liver samples were also collected for further assay. SG significantly decreased the serum levels of glucose, insulin, aspartate transaminase (AST), alanine aminotransferase (ALT). In addition, SG increased superoxide dismutase (SOD) activity and inhibited malondialdehyde (MDA) content in serum. SG also ameliorated the histopathological condition. Furthermore, SG attenuated the expressions of thioredoxin (Trx), thioredoxin-interacting protein (Txnip) and the phosphorylations of inhibitory kappa B kinase (IKK)α, IKKβ, nuclear factor-κB inhibitory proteins (IκB)α, nuclear factor κB (NF-κB). These findings demonstrated that SG showed beneficial effects on STZ-induced diabetic rats.
本研究旨在探讨槐黄酮G（SG）对链脲佐菌素（STZ）诱导的糖尿病大鼠的保护作用。大鼠腹腔注射STZ（35mg/kg）。7天后，大鼠连续30天每天灌胃给予二甲双胍（MET，150mg/kg）、SG（20mg/kg）或SG（40mg/kg）。将动物麻醉后，采集血液和肝脏样本用于进一步检测。SG显著降低了血清葡萄糖、胰岛素、天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）水平。此外，SG增加了血清中超氧化物歧化酶（SOD）活性并抑制了丙二醛（MDA）含量。SG还改善了组织病理学状况。此外，SG减弱了硫氧还蛋白（Trx）、硫氧还蛋白相互作用蛋白（Txnip）的表达以及抑制性κB激酶（IKK）α、IKKβ、核因子κB抑制蛋白（IκB）α、核因子κB（NF-κB）的磷酸化。这些发现表明SG对STZ诱导的糖尿病大鼠具有有益作用。
