Biersack H J, Coenen H H, Stöcklin G, Reichmann K, Bockisch A, Oehr P, Kashab M, Rollmann O
Department of Nuclear Medicine, University of Bonn, FRG.
J Nucl Med. 1989 Jan;30(1):110-2.
Carbon-11-labeled amino acids have been successfully used to image brain tumors by PET. This study was undertaken to evaluate the potential of L-3-[123I]-iodo-alpha-methyl tyrosine (123IMT) for metabolic imaging of brain tumors. Ten patients (glioblastoma, oligodendroglioma, lymphoma, and metastases) had early and delayed brain SPECT with a rotating gamma camera after i.v.-injection of 200-300 MBq 123IMT. In nine patients the tumors showed intense uptake of the radiotracer. Tumor-to-brain tissue ratios were between 1.4 and 2.6. 123IMT shows potentials for monitoring the effects of brain tumor therapy.
碳-11标记的氨基酸已成功用于通过正电子发射断层扫描（PET）对脑肿瘤进行成像。本研究旨在评估L-3-[123I]-碘-α-甲基酪氨酸（123IMT）在脑肿瘤代谢成像中的潜力。10例患者（胶质母细胞瘤、少突胶质细胞瘤、淋巴瘤和转移瘤）在静脉注射200-300MBq 123IMT后，使用旋转γ相机进行了早期和延迟脑单光子发射计算机断层扫描（SPECT）。9例患者的肿瘤显示出对放射性示踪剂的强烈摄取。肿瘤与脑组织的比值在1.4至2.6之间。123IMT显示出监测脑肿瘤治疗效果的潜力。
