Antimisiaris Sophia G
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, 26510, Rio, Patras, Greece.
FORTH/ICE-HT, 26510, Rio, Patras, Greece.
Methods Mol Biol. 2017;1522:23-47. doi: 10.1007/978-1-4939-6591-5_3.
Dried reconstituted vesicles (DRV) are liposomes that are formulated under mild conditions and have the capability to entrap substantially high amounts of hydrophilic solutes (compared to other types of liposomes). These characteristics make this liposome type ideal for entrapment of labile substances, as peptide, protein, or DNA vaccines, or in general biopharmaceuticals and sensitive drugs. In this chapter, all possible types of DRV liposomes (with respect to the encapsulated molecule characteristics and/or their applications in therapeutics) are introduced, and preparation methodologies (for each type) are described in detail.
干燥重构囊泡（DRV）是在温和条件下制备的脂质体，与其他类型的脂质体相比，能够包封大量亲水性溶质。这些特性使这种脂质体类型非常适合包封不稳定物质，如肽、蛋白质或DNA疫苗，或一般生物制药和敏感药物。在本章中，介绍了所有可能类型的DRV脂质体（根据包封分子的特性和/或它们在治疗中的应用），并详细描述了（每种类型的）制备方法。
