Antimisiaris Sophia G
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, and ICE-HT/FORTH, Patras, Greece.
Methods Mol Biol. 2010;605:51-75. doi: 10.1007/978-1-60327-360-2_3.
Dried reconstituted vesicles (DRV) are liposomes that are formulated under mild conditions and have the capability to entrap substantially high amounts of hydrophilic solutes (compared with other types of liposomes). These characteristics make this liposome type ideal for entrapment of labile substances, as peptide, protein or DNA vaccines and sensitive drugs. In this chapter, we initially introduce all possible types of DRV liposomes (in respect to the encapsulated molecule characteristics and/or their applications in therapeutics) and discuss in detail the preparation methodologies for each type.
干燥复溶囊泡（DRV）是在温和条件下制备的脂质体，能够包封大量亲水性溶质（与其他类型的脂质体相比）。这些特性使这种脂质体类型成为包封不稳定物质（如肽、蛋白质或DNA疫苗以及敏感药物）的理想选择。在本章中，我们首先介绍DRV脂质体的所有可能类型（根据包封分子的特性和/或它们在治疗中的应用），并详细讨论每种类型的制备方法。
