腹腔内注射万古霉素的全身毒性

Systemic Toxicity of Intraperitoneal Vancomycin.

作者信息

Kumar Teerath, Teo Iris, McCormick Brendan B

机构信息

Division of Nephrology, Department of Medicine, University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada; Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada.

Department of Pathology, University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada.

出版信息

Case Rep Nephrol. 2016;2016:3968690. doi: 10.1155/2016/3968690. Epub 2016 Oct 20.

DOI:10.1155/2016/3968690

PMID:27840751

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5093231/

Abstract

Intraperitoneal vancomycin is used for empiric treatment of peritoneal dialysis peritonitis. It is dosed intermittently and a high systemic concentration is often achieved. Despite this, there are very few reports of systemic toxicity from intraperitoneal vancomycin. We report the course of a patient who developed a drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome after three weeks of intraperitoneal vancomycin. We review the literature and conclude that this is the first ever reported case of DRESS syndrome from intraperitoneal vancomycin.

摘要

腹腔内使用万古霉素用于腹膜透析相关性腹膜炎的经验性治疗。它采用间歇性给药，常常会达到较高的全身浓度。尽管如此，关于腹腔内使用万古霉素导致全身毒性的报道却非常少。我们报告了一例患者，在腹腔内使用万古霉素三周后发生了伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）综合征。我们查阅了文献并得出结论，这是首例有报道的腹腔内使用万古霉素导致DRESS综合征的病例。