Baker D, Kimber I, Turk J L
Department of Pathology, Royal College of Surgeons of England, London, United Kingdom.
Cell Immunol. 1989 Mar;119(1):153-9. doi: 10.1016/0008-8749(89)90231-1.
Skin painting of guinea pigs with either 4-ethoxymethylene-2-phenyloxazol-5-one or 2,4-dinitrofluorobenzene induced not only a primary proliferative response in the draining lymph node but also the systemic suppression of subsequent proliferative responses to topically applied hapten. The inhibition of lymphocyte proliferation, as assessed by the incorporation of [3H]-thymidine and the presence of large pyroninophilic cells in the paracortex, was hapten-specific and long-lasting. This study demonstrates that, in common with the mouse, the sensitization of guinea pigs results in the induction of a hapten-specific suppressor mechanism, which serves to control the proliferative response following reexposure to hapten. However, the antigen-nonspecific suppression of proliferation observed in the mouse following exposure to some potent contact sensitizers was not, under the conditions employed, detectable in the guinea pig.
用4-乙氧基亚甲基-2-苯基恶唑-5-酮或2,4-二硝基氟苯对豚鼠进行皮肤涂抹，不仅会在引流淋巴结中引发原发性增殖反应，还会对随后局部应用半抗原的增殖反应产生全身性抑制。通过[3H]-胸腺嘧啶核苷掺入以及副皮质中大量嗜派洛宁细胞的存在来评估，淋巴细胞增殖的抑制具有半抗原特异性且持久。这项研究表明，与小鼠一样，豚鼠致敏会诱导半抗原特异性抑制机制，该机制用于控制再次接触半抗原后的增殖反应。然而，在所用条件下，小鼠接触某些强效接触性致敏剂后观察到的抗原非特异性增殖抑制在豚鼠中未检测到。
